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鐢寵鍙?CN202411729997.4
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鐢寵鏃ユ湡:20241129
涓撳埄綾誨瀷:鍙戞槑
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鎺堟潈鏃?20250314
鎽樿:鏈彂鏄庡叕寮�浜嗕竴縐嶇敤浜庢枒鑺傚铏懼熀鍥犵紪杈戠殑OpenCRISPR NLS铻嶅悎铔嬬櫧鍙婂叾鏋勫緩鏂規(guī)硶浠ュ強鍖呭惈鎵�榪癘penCRISPR NLS铻嶅悎铔嬬櫧鐨勬牳鑻烽吀鏋勫緩浣?榪樺叕寮�浜嗕笂榪拌瀺鍚堣泲鐧芥垨鎵�榪版牳鑻烽吀鏋勫緩浣撳湪鏂戣妭瀵硅櫨鍩哄洜緙栬緫涓殑搴旂敤浠ュ強鍦ㄦ按浜у吇孌栨枒鑺傚铏劇殑縐嶇兢鏀硅壇涓殑搴旂敤銆傛湰鍙戞槑閫氳繃瀵筄penCRISPR 1铔嬬櫧鐨勭紪鐮佸簭鍒楄繘琛屽瘑鐮佸瓙浼樺寲浠ュ強灝嗘牳瀹氫綅淇″彿(NLS)涓庣粡榪囧瘑鐮佸瓙浼樺寲鐨凮penCRISPR铔嬬櫧铻嶅悎,鍏鋒湁楂樻晥鐨勫熀鍥犺〃杈俱�佺簿鍑嗙殑闈跺悜瀹氫綅鑳藉姏銆佷紭瓚婄殑鍩哄洜緇勭紪杈戞晥鐜囥�侀檷浣庤劚闈舵晥搴斻�侀�傚簲鎬у箍娉涖�佹帹鍔ㄥ彲鎸佺畫鐨勬按浜у吇孌栦互鍙婂叿鏈夋樉钁楃殑緇忔祹鍜岀ぞ浼氫環(huán)鍊肩瓑浼樼偣銆?/p>
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綺ゅ叕緗戝畨澶?4010502001742鍙?/a>